vcclab.org. Overview of the many logP and other physical property calculators available commercially and on-line. XLOGP3, a simple LogP estimator used by PubChem (release 2021.05.07)

Nov 17, 2025 · LogP and logD are important values to consider during drug design as both give insight to the lipophilicity and hydrophilicity of compounds.

LogP is the log of the partition coefficient of a solute between octanol and water, at near infinite dilution. LogP is widely used in drug discovery and development as an indicator of potential utility of a solute …

Jan 6, 2024 · LogP measures the logarithm of ration between the concentration of a compound in a non-polar solvent and in water. It is common practice to measure this using octanol (PubChem 2003) as …

Due to the importance of the drug lipophilicity, logP is a component of the Lipinski rule of five. 1 LogP is defined as the partition coefficient of a molecule between aqueous and lipophilic phases usually …

The logP value, representing a compound's partition coefficient between octanol and water, is a critical parameter in computer-aided drug design (CADD) and various molecular applications due to its …

Examples for logP and logD calculations The following examples show log P /log D results for special molecules types. The calculations were performed with the default settings of the log P plugin. …

Introduction Symbols Definition of Partition Coefficient P and Distribution Coefficient D Micro Partition Coefficient Relation Between Macro and Micro Partition Coefficients LogP calculation methods …

Octanol-water partition coefficient logP is used in QSAR studies and rational drug design as a measure of molecular hydrophobicity. Hydrophobicity affects drug absorption, bioavailability, hydrophobic drug …

Sep 3, 2022 · LogP gives you an indication of how well the molecule will partition into the organic elution solvent. The higher the logP, the more likely the compound will partition from the SLE phase into the …