The selective serotonin (5-HT) and norepinephrine (NE) reuptake inhibitors (SNRIs) are commonly used for the treatment of neuropathic pain and fibromyalgia. Ammoxetine ((±)-3-(benzo[d] ...

Male Sprague–Dawley rats (weight 250–350 g, Japan SLC, Shizuoka, Japan) were used. The animals were housed in a light-controlled room with a 12-h light/dark cycle and were allowed ad libitum access to ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 68, No. 3 (Mar., 1971), pp. 662-666 (5 pages) ...

Methylphenidate (Ritalin) elevates norepinephrine levels in the brain to help focus attention and suppresses nerve signal transmissions in the sensory pathways to help block out extraneous stimuli.

Norepinephrine (NE) and noradrenaline (NA) are two different terms used to describe the same thing. In the United Kingdom, "noradrenaline" is the British-approved name for this neurotransmitter and ...

Although millions depend on medications such as Ritalin to quell symptoms of attention deficit hyperactivity disorder (ADHD), scientists have struggled to pinpoint how the drugs work in the brain. But ...

PROMINENT among the symptoms of familial dysautonomia are the manifestations of autonomic dysfunction. 1 A disturbance in catecholamine metabolism has been documented by the demonstration of high ...

Our most popular blog post last year was all about dopamine, the sexiest of the brain’s chemical signals involved in ADHD. Dopamine is sexy, and has even become a bit of an internet meme, because of ...

The abnormality in catecholamine metabolism has now been further explored by measurement of the catecholamine content of the adrenal glands and heart muscle of children dying with dysautonomia. The ...